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However, these effects were completely blunted in NaCl-restricted subjects, despite GH-stimulated renal ammonia production as suggested by increases in urine pH, and could be restored after changing back to a normal NaCL diet

Acromegalic patients often present with mild hyperphosphatemia despite increased GFR, due to increased TmP/GFR, which can be used as a comprehensive measure of disease status and can be reversed with treatment [107]

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