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found that 4 could bind to IKK through the covalently binding of Cys179 in IKK [126]

Disease: Evidence suggests that disease states generally have a negative effect on drug metabolism capacity

This medication was shown to be converted to morphine in some patients

This hypothesis is consistent with our results showing that curcumin binds to several enzymes functioning in the ROS metabolic pathway and regulating intracellular ROS levels, which trigger p53-dependent and -independent checkpoint pathways, resulting in apoptosis or senescence 23,24,25,26,27

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