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This is consistent with the methyl folate trap hypothesis (54), which predicts that, in vitamin B-12 deficiency, the inhibition of DNA synthesis and cell proliferation is removed upon administration of high doses of folic acid because of increased availability of nonmethylated folate

Treatment also produces beneficial changes in plasma lipid profiles, decreasing total cholesterol levels by approximately 30%, bringing these values to levels comparable with normal-weight controls

The NICE recommendations tell GPs to consider testing in anyone with one symptom or one risk factor, and to treat early to prevent neurological damage that can become permanent

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Though human data remains sparse