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Participants were required to abstain from alcohol from 24 hours before until 24 hours after each dosing, refrain from caffeine and nicotine on imaging visit days and not drive or operate machinery from the time of dosing until 24 hours postdose

NNMT is upregulated in the white adipose tissue of obese animals and humans, and its activity is mechanistically linked to depleted cellular NAD+ and SAM pools

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