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Consistent with the results, the IC 50 values of PEG-T ECM -NS/OLE in 4T1 cells with or without pH 6.8 buffer treatment were 0.826 and 4.75 g mL 1 , respectively (Fig

O is able to either reduce or oxidize transition metals (e.g., iron, copper) ( destroys the Fe-S clusters of proteins, and the reduced iron undergoes additional redox reactions that cause more injuries, as described below ( Hydrogen peroxide As shown in Reaction 2, Fe(II) returns to the oxidized Fe(III) state, in the process catalyzing the production of H 2 O 2

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