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Allegra E, et al

Cisplatin exerts its cytotoxic effects through a complex interplay of molecular mechanisms, primarily by coordinating DNA to form platinumDNA adducts, resulting in DNA damage, mitochondrial dysfunction, reactive oxygen species (ROS) generation, modulation of cell death pathways and subsequent apoptosis [7]

Although it is not possible at this stage to identify the mechanisms at the basis of the upregulation of mitochondrial respiration promoted by the presence of the TDP-43 G376D , it is likely that the increased amount of ATP required by the cells to counteract the effect of the mutation drives the upregulation of mitochondrial respiration