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Our endeavor was to elucidate the role of oxidative stress in the occurrence and advancement of AD through a comprehensive analysis of existing studies

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Concurrently, SCFAs activate enterochromaffin cells (ECCs) to upregulate tryptophan hydroxylase 1 (TPH1) transcriptionthe rate-limiting enzyme for 5-HT biosynthesis from tryptophan (Reigstad et al., 2015)

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An example of this in relation to glutathione depletion is in acetaminophen (paracetamol) overdose, where the acute poisoning causes a severe and dramatic loss of cellular glutathione, especially in the liver