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NR is assessed in all offspring (male and female) at PND 1214 under the two screening studies for reproductive toxicity (TG 421 and TG 422) ( A statistically significant change in nipple retention should be evaluated similarly to an effect on AGD as both endpoints indicate an adverse effect of exposure and should be considered in setting a NOAEL . Assessment of permanent nipples in mature males is not specifically mandated in any OECD TG, but only suggested indirectly in that abnormalities should be recorded at necropsy

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