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Smith LK, White CW, 3rd, Villeda SA

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Composed of c-Jun and c-Fos, AP-1 is activated by ROS and synergizes with NF-B to enhance pro-inflammatory factor transcription, while participating in the regulation of airway epithelial cell squamous metaplasia (27)

34 , 37 This comprehensive exploration of family, gender, and ethnicity deepens our understanding of the multifaceted factors contributing to premature graying, offering valuable insights into its diverse manifestations across populations (Table 1)