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Studies suggest that IGF-1 LR3 might activate key signaling pathways, including the phosphoinositide 3-kinase (PI3K)/Akt and mitogen-activated protein kinase (MAPK) cascades, both of which are central to cellular proliferation and survival

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Prior to treatment, [ 89 Zr]Zr-DFO-daratumumab could serve as a predictor for the tumor's response to daratumumab therapy, and as biomarker for monitoring the response to daratumumab therapy [65]