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Recent studies have also focused on the fine regulatory mechanisms of inflammatory response, such as the activation of NLRP3 inflammasome in sensing various danger signals (Seoane et al., 2020), and the complex role of Hypoxia-inducible factors (HIFs) in regulating inflammation and immune response (Foglia et al., 2021)

Synergistic interactions between GSTs and efflux pumps have also been observed in several studies 68,70

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