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Over the last 30 years the number of diagnosed cases has increased from 0.4-0.5 to 4.0 per 1000 for autistic disorder and from 2 to 7.7-9.9 per 1000 for autism spectrum disorders [13] which is largely attributable to broadening diagnostic criteria, younger age at diagnosis and improved case ascertainment [4]

This process involves cancer cells invading surrounding extracellular barriers and basement membranes, infiltrating into vascular lumens, extravasating into distant organs, colonizing, and adapting to foreign tissue microenvironments [105,106,107]

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Science 334, 17271731

Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: a systematic review and meta-analysis