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Common side effects in the central nervous system include: trouble sleeping mild anxiety feeling jittery or irritable Rare side effects include: fatigue extreme anxiety panic attacks mania hallucinations delusions feelings of paranoia Tell your doctor if you have a history of drug or alcohol use disorder

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Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade