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Frontiers in Nutrition 10

Thus, precise control of the metabolic pathway of Met is critical for maintenance of optimal cellular function, which is well worth a deeper look

Although these inconcistencies are present, they do not hinder the validity of the AOP in its biological plausibility or empirical analsysis

Evidence of Parkin/PINK1-mediated mitophagy from patient iPSC-derived neurons Although mutations in Parkin or PINK1 were found to compromise mitophagy in cultured cells and animal models, direct pathological evidence is still lacking if the same mutations would impair mitophagy and if such defect is the key factor for the loss of DA neurons in vivo or in PD patients 49