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Dysfunction in mitochondria can lead to electron leakage in the electron transport chain, resulting in overproduction of ROS such as superoxide anions and hydrogen peroxide ( Endoplasmic reticulum oxidative stress: The endoplasmic reticulum (ER), responsible for protein synthesis and folding, is vulnerable to oxidative stress

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Methods: Data for DRFs was obtained from the Organ Procurement & Transplantation Network (OPTN) website via the US Department of Health & Human Services, and the Health Resources & Services Administration (HRSA), and was cross-referenced using Google Maps and direct contact with organ procurement organization staff

Metabolic response in the late 72 h reperfusion time suggests that neural cells accelerate glutamate metabolic recovery to substitute the deprivation induced by ischemic event and presumably compensate for the altered synthetic function of damaged neural cells