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33 As previously discussed, genetic mutations leading to leptin receptor deficiencies or leptin insufficiency support the idea that this peptide plays a crucial role in long-term energy homeostasis

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The peptide chelates free copper ions that could otherwise participate in pro-oxidant Fenton reactions, while simultaneously stimulating the expression of endogenous antioxidant enzymes such as superoxide dismutase, catalase, and glutathione peroxidase

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