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Further studies are necessary to clearly delineate the major NAD + biosynthetic pathways and NAD + consumption routes during macrophage phenotypic transition to determine whether the observed decline in NAD + levels depends on context and time and to determine the molecular mechanisms through which NAD + levels alter macrophage polarization states and functions

Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy

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