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Larger Phase IIb trial: development terminated In 2007, a larger 24-week trial with 536 subjects failed to demonstrate weight loss significant enough to support pharmaceutical viability

Thus, while the estimation of the amount of a loading dose may be quite correct, the rate of administration can sometimes be crucial in preventing excessive drug concentrations, and slow administration of an intravenous drug (over minutes rather than seconds) is almost always prudent practice

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For reference, this is substantially higher than the equivalent human doses typically used