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In HepG2 cell line, core protein expression results in the suppression of Sirtuin 1 expression at the origin of the upregulation of PEPCK and glucose-6-phosphate dehydrogenase (G6PD) and downregulation of glucose transporter 2 (GLUT2) (90, 91)

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GSH is a powerful antioxidant that neutralizes free radicals that interfere with lipidic, proteic, enzimatic and DNA metabolism

In cancer cells, heightened oxidative stress results from increased ROS production and/or compromised ROS-scavenging capacity [8]

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