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Eicosanoid class switching A process by which pro-inflammatory eicosanoid synthesis changes to anti-inflammatory or pro-resolution eicosanoid and docosanoid synthesis

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5,6 For example, free radicals play a role in detoxification of xenobiotics by oxidizing enzymes, in killing of microorganisms by macrophages and cytotoxic lymphocytes, and in the generation of prostaglandins and leukotrienes, which activate oxygenases (e.g., cyclooxygenases and lipoxygenase) and thus act as modulators of the inflammatory response

This is the phase where the synergistic effects become most apparent

Conclusion ASD is a substantial global issue due to the annual rise in case numbers