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Within the vascular system, oxidized low-density lipoprotein enhances superoxide generation through multiple pathways, including the induction of uncoupled endothelial NOS, activation of NADPH oxidase and xanthine oxidase enzymes, and disruption of mitochondrial electron transport chain function [139]

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Growth factors and cytokines are the main activators of the ERK pathway as a result of ligand-stimulated tyrosine kinase receptors (RTKs)

In addition, the emergence and dissemination of resistant bacterial strains are compounded by the practice of uncontrolled using antibiotics as growth promoters to increase poultry production (Oliver et al., 2011)

In genetically susceptible individuals, the immune system doesnt successfully clear the biotoxin signal, and inflammation continues even after the source of exposures been removed