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In previous studies, IL-12 / 23 inhibitors have shown certain efficacy in psoriasis and Crohns disease, but in this case, IL-12 / 23 inhibitors failed to improve skin lesions, which may be related to the less use of IL-12 / 23 inhibitors only once, the serious clinical manifestations of patients and the long-term use of IL-17 inhibitors [16]

Glutamate is the most abundant excitatory transmitter in the central nervous system, utilized at 50- 70% of cortical synapses (1, 2)

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