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In the purine pathway, in addition to uric acid, studies have also identified inosine, an endogenous purine, as capable of downregulating the TNF-, IL-1, IL-6, and Macrophage inflammatory protein-2 (MIP-2) expression induced by LPS, and reducing MIP-1 (Figure 4)

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[24] More recent positive results of long-term treatment with azithromycin on asthma exacerbations and quality-of-life in patients with severe, refractory asthma [25] [26] have resulted in azithromycin now being recommended in international guidelines as a treatment option for these types of patients

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Previously, we showed that loss of the circadian clock increased oxidative damage and caused neurodegenerative changes in the brain, while enhanced GSH production in neuronal tissue conferred beneficial effects on fly survivorship under normal and stress conditions