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Regulation of apoptosis signal-regulating kinase 1 in redox signaling

40(12): 130510 Rebouche CJ, Engel AG

3.1 Cellular consequences of macrophage lipotoxicity Excessive intracellular accumulation of FFAs, termed lipotoxicity, can promote pro-inflammatory responses, disrupt cellular homeostasis, induce organelle dysfunction, and ultimately induce cell death in macrophages (69, 70, 80)

* Plasma samples were collected for all 53 participants, whereas urine samples were collected for 51 of the 53 participants (subjects 19 and 21, both females, did not provide urine samples)