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Glossary SIRT1 Silent information regulator 1 MASLD Metabolic Dysfunction-Associated Steatotic Liver Disease MASH Metabolic Dysfunction-Associated Steatohepatitis ALD alcoholic-associated liver disease HCC hepatocellular carcinoma NAD nicotinamide adenine dinucleotide CTR C-terminal regulatory segment NF-B nuclear factor kappa-light-chain-enhancer of activated B cells p53 tumor protein 53 PGC-1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha Nrf2 nuclear factor erythroid 2-related factor 2 miRNAs microRNAs SOX2 sex determining region Y-box 2 CSCs cancer stem cells FOXO3 Forkhead box O3 FOXO1 Forkhead box O1 SOD superoxide dismutase SASP senescence-associated secretory phenotype SA- senescence-associated -Gal -galactosidase p21 cyclin-dependent kinase inhibitor 1 p16 cyclin-dependent kinase inhibitor 2A HSCs hepatic stellate cells LSECs liver sinusoidal endothelial cells CLD chronic liver disease NLRP3 NOD-like receptor protein 3 IL-1 Interleukin-1, beta ROS reactive oxygen species EET-A epoxyeicosatrienoic acid-agonist AMPK AMP-activated protein kinase ECM extracellular matrix HO-1 heme oxygenase-1 HMGB-1 high mobility group box 1 TLR4 toll-like receptor 4 PPAR peroxisome proliferator-activated receptor TGF-1 transforming growth factor beta 1 -SMA alpha-smooth muscle actin CLI cholestatic liver injury Akt protein kinase B RSV resveratrol PSC primary sclerosing cholangitis CYP2E1 cytochrome P450 2E1 SREBP1 sterol regulatory element-binding protein 1 LKB1 liver kinase B1 HFD high-fat diet TTP Tristetraprolin TNF- tumor necrosis factor- JNK c-Jun N-terminal kinase LC3 microtubule-associated protein 1 light chain 3 USP22 ubiquitin-specific peptidase 22 YAP2 yes-associated protein 2 PI3K phosphoinositide 3-kinase References 1 Abd-EllaE

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