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490 Furthermore, Sir2 , as a mammalian homolog of SIRT1, is the downstream effector of increased Nmnat activity, which can lead to axon protection in Wallerian degeneration slow mice

Additionally, erythrocytes generate ROS due to hemoglobin autooxidation, Fenton reaction, NADPH oxidase- and xanthine oxidoreductase-mediated reactions, and scavenge exogenous immune cells-derived ROS [17]

This interindividual variability has led to the classification of three urolithin metabotypes: the UM-A strain is distinguished by its predominant production of urolithin A, while the UM-B strain produces urolithins A and B, along with their isomers

Atamer Y, Sarac S, Asik HK, Sahbaz T