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The potential of apigenin to combat a variety of cancers by initiating programmed cell death, inducing cell-cycle arrest, decreasing metastatic behavior, and preventing tumor vascularization is further demonstrated by experimental data from in vitro and in vivo investigations

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However, in evolutionary context it makes sense, as Met-derived GSLs are a later invention in plant evolution (both in comparison to other types of GSL and other types of secondary metabolites), and during evolution plants made use of already existing transporters from primary metabolism

doi: 10.1016/j.nut.2012.11.012 145 MahanDCClineTRRichertB

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