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Because the unusual bond formed through the gamma-carboxyl group of glutamate can only be hydrolyzed by one enzyme, gamma-glutamyltranspeptidase, which is present only on the external surfaces of certain cells

Also, the nonselective distribution of drug carriers and the breakdown of pharmaceuticals during gastrointestinal transport may have hazardous effects [30]

When taken this way, enzymes in the stomach and intestines may destroy much of the glutathione, meaning only a small portion enters circulation

This therapeutic resistance largely stems from GSHs strong antioxidant and detoxifying functions [17]

Extinction coefficients of HT adducts were measured in the presence of a twofold excess of HT protein to ensure quantitative reaction of the ligand