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For example, cytomegalovirus (CMV) infection of the adult cochlea, unlike during the prenatal period, typically causes mild hearing loss and cochlear damage (Juanjuan et al., 2011

Typical experimental endpoints include measures of collagen and extracellular matrix protein expression, cell migration rates, cytoskeletal organization, and transcriptional changes in genes related to tissue structure and repair, depending on the model

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In severe cases, this can lead to muscle weakness, cramps, and even muscle pain, due to nerve damage from long-term deficiency

Finkel T, Holbrook NJ (2000) Oxidants, oxidative stress and the biology of ageing