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Lipid Droplets in Cancer: Guardians of Fat in a Stressful World

An antisense oligonucleotide selective inhibitor of apoCIII has been developed that lowers serum apoCIII and triglycerides in mice, non-human primates, and humans and is currently in a phase 2 clinical trial (653)

Brain resting-state network alterations associated with Crohns disease

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While caspases-4, -5 and murine caspase-11 are all capable of directly binding to LPS, differences in their binding capabilities to alternative LPS forms exist and the route of LPS internalisation may also influence their activation, as demonstrated by the selective activation of caspase-5 by OMVs from P