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Nuclear translocation of glutathione S-transferase pi is mediated by a non-classical localization signal

Therefore, depletion of NADPH stores in G6PD-d has the potential to both limit the production of ROS by NOX family enzymes, while simultaneously expediting the accumulation of ROS from non-NADPH-dependent sources, such as the mitochondrial electron transport chain, peroxisomal -oxidation, oxidative protein folding, and other cytoplasmic enzymes (xanthine oxidase, cyclooxygenase, lipoxygenase) 95,96

This delivery method is believed to enhance the absorption and bioavailability of glutathione

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a single dose of 2 grams in the second trial