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These differences are undoubtedly the result of differences in pharmacokinetic features, lipid solubility, ability to penetrate the central nervous system (CNS), membrane transport properties, detoxification reactions, and specific enzymatic reactions capable of repairing alkylation sites on DNA

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Further knowledge of these metabolic processes, at other levels beyond the availability of substrate, will be necessary for us to be able to modulate with more accuracy these events to the benefit of the whole organism