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In: Emerging Trends in Dietary Components for Preventing and Combating Disease 303322 Reisman D, Takahashi P, Polson A, Boggs K (2012) Transcriptional regulation of the p53 tumor suppressor gene inS-phase of the cell-cycle and the cellular response to DNA damage

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Biochem Biophys Res Commun 205(2):10641071 Cederbaum AI et al (2012) CYP2E1 sensitizes the liver to LPS- and TNF -induced toxicity via elevated oxidative and nitrosative stress and activation of ASK-1 and JNK mitogen-activated kinases

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Remarkably, TLR3-induced activation of TBK1 and IRF3 was unaffected in these cells whereas, consistent with our prior observations 10 , TNF-induced TBK1 activation was completely lost in the absence of these three proteins (Fig