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Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair

This stimulates the peroxidation of the lipid components of biological membranes, the damage from which results in aging

For example, patients with Type 2 Diabetes Mellitus (T2DM) and diabetic comorbidities have lower plasma SOD activity and lower GSH concentrations [126]

These cells develop from monocytes exposed to IL-2, and are part of the specific immune system that look for and destroys abnormal cells such as tumor cells