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They detect and attach to high-affinity sulfonylurea receptors, which are potassium-selective ion channel proteins abundantly expressed on ER membranes

Coenzyme Q10 attenuates beta-amyloid pathology in the aged transgenic mice with Alzheimer presenilin 1 mutation

doi: 10.1016/j.parint.2013.12.003 [DOI] [PubMed] [Google Scholar] 45

These interactions have been proposed as a mechanism through which the peptide may influence gene expression programs associated with cellular senescence (Vanyushin et al., Biochemistry (Moscow), 2014)