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Curtis, MD, MS, MPH, a professor of medicine in the division of clinical immunology and rheumatology at the University of Alabama at Birmingham (UAB), told the American College of Rheumatology in a press release

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To improve the precision, your practitioner will numb the area with the help of local anesthetic agent before administering ethanol injection

Here are some tips: Avoid freeze-thaw cycles : Repeated freezing and thawing can reduce the compounds biological activity