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Participants whose diets were low in dietary fiber experienced marked increases in butyrate production in their guts, likely due to increases in butyrate-producing microbes

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While some studies suggest a relationship between B12 status and bone mineral density, evidence does not currently show that supplementation prevents fractures in people without deficiency

National Institute on Drug Abuse

Together, these results support that Cys180 is the critical residue that MeCbl directly coordinates to GSDME, thereby inhibiting GSDME-mediated pyroptosis