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Saulnier et al., 2013)

Curr Med Res Opin 2005;21:2:255-60

In contrast, in situ vaccination triggers a robust local inflammatory response that not only primes CTLs but also facilitates epitope spreading, thereby enhancing the breadth and durability of the systemic antitumor immune response

In addition, interventions that reduce intrahepatic triglyceride content through modest weight loss or leptin treatment dramatically reverse hepatic insulin resistance in T2DM, NAFLD, and lipodystrophic patients [83]