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3.1 DNA methylation and gene expression in CL In corpus luteum (CL) formation and functioning, epigenetic changes, and particularly DNA methylation are critical to gene expression regulation ( de novo methyltransferase ( Methylation of DNA normally occurs on CpG dinucleotides and is linked to transcriptional silencing ( The epigenetic control is also found in genes that are involved in the development of the vascular system such as vascular endothelial growth factor (VEGF), among others ( In luteal cells, DNA methylation dynamically regulates the transcription of steroidogenic genes