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It is worth noting that the results of the Phase 3 PHOENIX trial of AMX0035 were not satisfactory, and the manufacturer has initiated a market withdrawal procedure

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Recombinant GPX3 (rGPX3) has been shown to inhibit the cellular senescence of liver cells in a dose-dependent manner, with genes such as CD44 , Nox4 , IFNG , and SERPERINB2 identified as mediators of the suppressive effects of GPX3 on hepatic senescence [171]