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Pathophysiology beyond dopaminergic neuronal loss The alpha-synuclein model Alpha-synuclein is a presynaptic neuronal protein whose abnormal aggregation into Lewy bodies leads to disruption in cellular homeostasis and consequently neurodegeneration 7

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While -tocopheryl nicotinate can be prescribed as a lipid-lowering agent in Europe and Japan, it is marketed as a supplement only in the US (119)

10.1101/gad.340695.120 103

The increased MG in patients that died correlated inversely with the levels of the MG-degrading enzyme glyoxalase-1 ( r 2 = 0.50), and its co-factor glutathione ( r 2 = 0.63), and positively with monocytes ( r 2 = 0.29)