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Acknowledgements The authors thank the technical and administrative staff of IRCCS MultiMedica for their support

The ALA dosage started at 1200 mg/day, then it was increased if the effect was not sufficient, or decreased if side effects were observed

The study protocol was approved by the Independent Bioethics Committee for Scientific Research at the Medical University of Gdansk (NKBBN/354 201/2017) and registered in the ClinicalTrials.gov Registry (NCT05120011)