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Collectively, our findings demonstrate that MAT2A promotes SRF SUMOylation, thereby increasing its protein stability and nuclear retention, which in turn enhances SRF-dependent transcriptional activation of PARN

Target specific tight junction modulators

Mechanistically, circadian control of CI probably reflects the intersection of substrate routing and time-of-day coordination of CI biogenesis, stability and activity

88 Wnt/-catenin signalling activity is reduced in the lung epithelial cells of COPD patients, and the mechanisms responsible for its downregulation include cigarette smoke and fibroblast-derived Wnt5a

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