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Disruption of both liver IGF-1 and ALS genes results in 8590% reduction in circulating IGF-1 levels and significant reduction in linear growth, suggesting that a threshold concentration of IGF-1 is necessary for normal growth [19]

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The affected genes span multiple functional categories: DNA repair (upregulation of multiple DNA damage response genes), antioxidant defense, stem cell markers, ubiquitin-proteasome pathway components, and multiple growth factors including TGF-beta and VEGF