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Once internalized, intracellular glutathione is depleted by the NPs, followed by a Fenton-like reaction that sustains ROS production

Implication of 14-3-3 and 14-3-3/ in proteasome inhibition-induced apoptosis of glioma cells

Therefore, inhibiting NLRP3 inflammasome activation to reduce downstream caspase-1 proteolytic activitythereby attenuating pyroptotic cell death and suppressing the maturation and secretion of pro-inflammatory cytokinesrepresents a validated strategy to alleviate inflammatory injury

The second option is exemplified by blocking of components of the complement system in diseases where complement deposition is driving pathology

M.BergstraS