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MauriPRiccioAMRossiRDi SilvestreDBenazziLDe FerrariLet alProteomics of bronchial biopsies: galectin-3 as a predictive biomarker of airway remodelling modulation in omalizumab-treated severe asthma patients

35 pmol/l

As a result, an accumulation of Lipid-OOH occurs: since GSH is the reducing co-substrate of GPX4, able to regulate the redox state of the cell-forming Lipid-OH (Figure 2A), GSH depletion can negatively regulate GPX4, triggering ferroptosis [19]

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Annu Rev Pharmacol Toxicol 62:255277