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The average diet supplies about 4 to 15 mcg/day of vitamin B12 in a protein-bound form that is available for absorption after normal digestion

Best Practice & Research Clinical Endocrinology & Metabolism, 2023;37(2), 101743.4 Weetman AP

Severe or frequent hypoglycemia is an indication for the modification of treatment regimens, including setting higher glycemic goals

Some researchers adjust escalation timing based on body weight and individual response, but the target doses themselves remain the same across the research population