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Patients who have a compromised gastrointestinal system (with a low production of intrinsic factor) are not able to absorb enough vitamin B12 from food or a pill form

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Additionally, it has been hypothesized that carriers with lower levels of circulating sRAGE are more likely to develop breast, lung, and liver cancer (3032)

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It is recommended that adults over the age of 50 increase their sources of vitamin B12 through diet, fortified foods, B12 shots, or other supplements that can increase their B12 consumption. (By The National Institutes of Health) GASTROINTESTINAL ISSUES AND B12 SHOTS Persons who have gastrointestinal issues are particularly predisposed to issues with B12 deficiencies