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Metabolomic analyses further reveal that SLE is associated with dysregulated amino acid metabolism, reduced short-chain fatty acids, and disrupted lipid homeostasis, which correlate with disease activity, renal injury, and increased atherosclerosis risk

Chen J, Costa LG, Guizzetti M

Skin Pharmacol Appl Skin Physiol 14:203209 Hikima T, Yamada K, Kimura T, Maibach HI, Tojo K (2002) Comparison of skin distribution of hydrolytic activity for bioconversion of -estradiol 17-acetate between man and several animals in vitro