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G., Gratuze M., Narasimhan S., Jain N., Koscal L

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Trop2-CAR-Ms selectively target Trop2-overexpressing tumors and promote NK and CD8 T cell proliferation, with peak IL-6 levels ~one-fifth of those seen with conventional CAR-T and no serious CRS events ( in vivo reprogramming strategy presents a promising approach to circumvent the complexities of ex vivo CAR manufacturing and mitigate potential systemic toxicities